Controlling hypertension in patients with comorbidities

Leon is a retired 62-year-old man referred for assessment of a raised serum creatinine of 145µmol/L (Normal range: 60-110).

He was diagnosed with hypertension at age 32. He is currently treated with atenolol 50mg daily, irbesartan 300mg plus hydrochlorothiazide 25mg daily (Avapro HCT), and amlodipine 10mg daily (Norvasc).