Does this trio of supplements reduce migraine frequency?

A pharmacist suggests magnesium and riboflavin with CoQ10 as a prophylaxis

A member of an online GP discussion board recently posted a question about the combination of magnesium, riboflavin and coenzyme Q10 (CoQ10) as prophylaxis to reduce migraine frequency, something that had been recommended by a pharmacist.


Curiously, this combination is described in eTG Complete (July 2018 edition) with the disclaimer that the “supporting evidence is not strong”.

So, what is the evidence?

Clinical question

What is the effect of the combination of oral magnesium, riboflavin and coenzyme