Will statins stave off dementia?

It’s a question worth asking, especially for patients with a family history of the disease

Jonathan, a 60-year-old businessman, recently visited for a health check.

He was well but raised the challenges of providing care for his father, who had advanced Alzheimer’s disease, and mentioned that he read on the internet that statins could be used to prevent dementia.

Jonathan wondered whether this was something he should take.

Clinical question

Can statins, used as prophylaxis, reduce the incidence of dementia?

What does the research evidence say?

Step 1: The Cochrane Library
The Cochrane Library has a relevant systematic review published in 2016 (search conducted November 2015) on the use of statins for the prevention of dementia.1

This is quite contemporary, but I did a quick check on TripDatabase as well for newer systematic reviews.

Step 2: