10 drugs that need dose adjustment in obesity

There's more to it than total body weight

Estimating the optimal drug dose for obese patients can be difficult, say pharmacologists.

fat paper people

That’s because simply basing maintenance doses on total body weight is risky, says Associate Professor Michael Barras from the University of Queensland.

Instead, individualised dosing based on the patient’s lean body weight is recommended.

“Using total body weight assumes that the pharmacokinetics of the drug are linearly scalable from normal-weight patients to those who are obese,” writes Dr Barras in Australian Prescriber.

“This is inaccurate," he