4 ways to switch antidepressants

Switching from one antidepressant to another is often necessary due to an inadequate treatment response or unacceptable adverse effects.

Up to two-thirds of patients with major depression fail to respond to their first antidepressant, research shows.

About a quarter of patients switched to a second antidepressant can be expected to achieve remission.

There is no evidence that switching between classes of antidepressants is more effective than switching within a class.

The ‘conservative switch’ is most appropriate in general practice