5 reasons to avoid off-label prescribing

The first study to examine adverse drug events due to off-label prescribing has found the practice does indeed increase risk for patients.

The general practice study in Canada shows adults taking drugs off-label are 44% more likely to have to discontinue the drug because of an adverse reaction than those taking a drug with an approved indication.

The most frequent adverse drug events are related to the gastrointestinal tract, nervous, respiratory and musculoskeletal systems. They include::

  • Akathisia from gabapentin for neurogenic pain;
  • Agitation associated with

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