5 reasons to avoid sedating antihistamines

Adverse effects include accidents and severe tissue injury

First-generation antihistamines should be avoided, according to clinical immunologists.

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The main concerns are their sedative properties and interference with rapid eye movement sleep, say Dr Katrina Randall and Dr Carolyn Hawkins.

Other reasons to avoid sedating antihistamines include:

  • They adversely affect school performance.
  • They cause aviation and car accidents.
  • Promethazine is associated with serious behavioural and other adverse effects in children under two.
  • Their anticholinergic effects can be particularly

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