Annual B12 checks advised for PPI users

Long-term users of acid-suppressant medications are at risk of vitamin B12 deficiency and should have their B12 levels monitored every 1-2 years, Australian researchers say.

People who take acid-lowering agents such as PPIs and H2 receptor blockers for a year or more are at increased risk of developing B12 deficiency, according to a meta-analysis conducted by Dr Sonya Binna Jung and colleagues at the University of NSW.

Their systematic review of four case–control studies and one observational study found that long-term acid-suppressant therapy was associated with an 

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