Anti-emetic proves effective in IBS

A generic drug widely used as an antiemetic relieves symptoms of irritable bowel syndrome with diarrhoea (IBS-D), say UK researchers.

Ondansetron, a 5-HT3 receptor antagonist, significantly improved stool consistency, lowered urgency scores and reduced frequency of defecation, the study of 120 patients and 21 healthy subjects showed.

Around 80% of patients on ondansetron reported a decrease in the number of days with loose stools, which was double the percentage reported with placebo, the researchers