Antibiotic doubles risk of kidney injury

Fluoroquinolone antibiotics may double the risk of acute kidney injury, US research suggests.

A study of hospital admissions of men aged between 40 and 85 found those currently taking the antibiotics were at increased risk of acute kidney injury, with ciprofloxacin the biggest culprit.

But the results showed no increased risk for patients who had a history of recent or past use.

No association was found between acute kidney injury and non-fluoroquinolone antibiotics such as amoxicillin or azithromycin.

Writing in the CMAJ, the study's authors said the "small, but significant" increased risk — additional case per 1529 patients — should prompt awareness about the adverse reaction.

"Although it is clear that the risk of death due to serious infections outweighs

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