Antidepressant placebo effect remains steady

The average placebo response rate for antidepressants in the acute treatment of major depression has remained steady at 35-40% over the past two decades.

The findings, from a large randomised trial, debunk the myth of rising placebo responses seen in antidepressant trials, the international researchers say.

The results also shed new light on the heated debate over the diminishing efficacy of antidepressant drugs.