Antidepressant study finds the sweet spot for dosing

The 20-40mg range achieves the best balance for efficacy, tolerability and acceptability

Patients treated for major depression are likely to obtain optimal benefit with the lower dose range of second-generation antidepressants, a large review of published and unpublished trial data has found.

Dr Jill Gordon
Dr Jill Gordon.

The findings, published in Lancet Psychiatry, will have clinical implications for some pharmacological treatment guidelines, the researchers say.

In a systematic review and dose-response