Ban codeine in children under 12: TGA

The TGA is following up its codeine rescheduling proposal with recommendations to ban the drug completely in children under 12 and restrict use in children aged 12-18.

The recommendations are based on a recent safety review that concludes that children who are ultra-rapid metabolisers of codeine are at risk of respiratory depression and death.

About 1-2% of people are ultra-rapid metabolisers of codeine, meaning they convert a higher proportion of codeine to morphine than the rest of the population, the review says.

This presents a higher risk in children because they are more susceptible to