Is Botox able to help with depression?

The idea that Botox (botulinum toxin A) could help with depression is being explored by, Allergan, despite the latest trial showing patchy results.

Based on the “facial feedback” hypothesis, which holds that facial movement can influence emotional experience, Allegan is hopeful the drug’s anti-wrinkle and anti-frowning formula can  be used to improve mood.

Anecdotal evidence suggests Botox is already used off-label for this purpose.

Yet results from a phase II study of almost 260 patients show that Botox is unable to