Call for caution on PPI prescribing

Anti-reflux drugs taken by millions of Australians can increase the risk of vitamin B12 deficiency, a large study suggests, prompting calls for doctors to "exercise vigilance".

US researchers have found strong links between long-term use of PPIs and histamine 2 receptor antagonists and patients' risk of developing the deficiency.

A new diagnosis of B12 deficiency was 65% more likely in patients who had been prescribed PPIs for two years or more, compared with people never prescribed them, the