Call for caution on proton pump inhibitors
Proton pump inhibitors should be prescribed at the lowest dose and for the shortest possible duration because of potential side effects, Canadian researchers warn.
They say use has expanded beyond the evidence base, which is putting patients at increased risk of adverse events.
The treatment has been associated with rebound heartburn after discontinuation, malabsorption of vitamin B12, iron and magnesium, an increased risk of infection with Clostridium difficile and possible increased risk of fractures in patients.
“PPIs should be used with caution in patients with cirrhosis and be reserved