Caution over antipsychotics for depression

Atypical antipsychotics­ can help alleviate major depression when antidepressants fail, but at a heavy cost of side effects, research finds.

When used as adjunctive therapy, atypicals deliver a significant, albeit "small-to-moderate", impact on depression symptom severity compared with placebo, a comprehensive new meta-analysis has concluded.

About nine patients need to be treated for one to display a clinical response,