Doubts over stress urinary incontinence drug

UPDATED: 17th November 2016

The antidepressant duloxetine does more harm than good when used off-label to treat female stress incontinence, a meta-analysis shows.

Although use of the drug led to a 14% decrease in episodes of stress incontinence and an increase from 64 to 67 on an incontinence quality-of-life score, these were small effects outweighed by the harms caused, researchers said.

The study comparing 958 women with stress incontinence taking 80mg duloxetine daily with a similar number on placebo was led by Dr Peter Götzche, the Cochrane collaboration co-founder famous for his contentious