Drug-resistant UTIs need longer follow-up

Patients with resistant Enterobacteriaceae seven times more likely to require a second antibiotic

Patients with a UTI caused by antibiotic-resistant bacteria need longer follow-up, say US researchers after their study found they are at much higher risk of treatment failure.

The research shows that those in the community with a UTI caused by extended spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R EB) are seven times more likely than those with a UTI caused by the non-resistant version of the bacteria to:

  • Have ongoing symptoms
  • Continued bacteria in their urine 
  • Require a second antibiotic

They are also four times more likely to receive an inappropriate initial antibiotic, which may have contributed to treatment failure, but didn’t fully explain the association with worse clinical outcomes, the University of Pennsylvania researchers report in Infection Control & Hospital Epidemiology.