Dual therapy in diabetes questioned

Combining metformin with insulin rather than using insulin alone does not reduce mortality or prevent cardiovascular disease in patients with type 2 diabetes, research suggests.

Pooling data from 23 randomised trials, researchers said they "were unable to find any evidence, or even a trend towards" improved all-cause or cardiovascular mortality with dual therapy.

This gap in the evidence was surprising, they said in the BMJ, given that guidelines almost