Evidence shows PPI risks are overblown

Paper refutes previous findings and highlights the pitfalls of observational studies

Recent studies linking proton pump inhibitors (PPIs) to an increased risk of stroke have been refuted in a paper that suggests previous results may be due to residual confounding.


PPIs have been linked to a host of chronic conditions, including premature death, a heightened risk of chronic kidney disease, dementia and bone fracture in people with osteoporosis.

But the latest study illustrates the pitfalls of using observational database studies to identify potential adverse effects.

In this analysis, which used data from two large prospective cohort studies including more than 97