Explained: how statins cause diabetes

The increased risk of diabetes with statins is due to weight gain mediated by the same target enzyme responsible for the drugs' lipid lowering effects, a new study shows.

A meta-analysis has confirmed that patients taking statins have a 12% higher risk of new-onset type 2 diabetes, and additional findings have linked this to the HMG CoA reductase enzyme responsible for lowering LDL-cholesterol.

Published in the Lancet, the analysis of data from 129,000 patients in randomised trials of statins showed that the drugs were