Familial hypercholesterolemia raises risk of two other diseases

Doctors should screen for PAD and CKD, researchers say

Patients with familial hypercholesterolemia (FH) are at increased risk of peripheral arterial disease and chronic kidney disease, a prospective study confirms.

Ankle-brachial index and eGFR are also independently associated with risk of MI in these patients, Danish researchers report in the Journal of Clinical Endocrinology & Metabolism

The findings suggest that patients with FH should be routinely screened for peripheral arterial disease, and those found to be high risk may benefit from more intensive lipid-lowering treatment, say the authors.

The authors looked at data from more than 106,000 participants in the Copenhagen General Population Study, including 6623 (6.2%) with possible FH and 488 (0.5%) with probable/definite FH based on Dutch Lipid Clinic Network criteria scores.

Individuals with possible or probable/definite FH were significantly more likely to