Febrile seizures still a risk with acellular vax

Paediatric combination acellular pertussis vaccines increase the risk of febrile seizures in infants, but do not predispose to subsequent epilepsy, research suggests.

A large study found a combined DTap-IPV-Hib vaccine was linked to a small, but significantly increased risk of febrile seizures in infants following the first and second dose, given at three and five months, respectively.

Compared with children not vaccinated in the preceding week, the risk of febrile seizures rose by four- to sixfold on the day of receiving the vaccine, the study