Increased cancer risk remains after CIN 3 treatment

Previous studies have shown that women previously treated for cervical intraepithelial neoplasia grade 3 (CIN 3) have an increased risk of developing cervical or vaginal cancer, and that this risk persists until at least 25 years after treatment.

However, no study has investigated how aging affects the risk of death from cervical cancer following treatment for CIN 3.

In this study, researchers in Sweden used data from the Swedish Cancer Registry to follow 150,883 women diagnosed and treated for CIN 3 in the period 1958–2008.

Of this group, 1089 had a diagnosis of invasive cervical cancer and 147 of vaginal cancer. Of those diagnosed with cancer, 302 and 53 respectively had died from the disease.

The researchers found there was an increased risk of invasive cervical or vaginal cancer as women previously treated for CIN 3 aged, accelerating after the age of 60. After the age of 75, incidence rates in this group increased further,