Off-label ketamine still a worry

Increasing numbers of doctors are offering ketamine as an off-label treatment for psychiatric disorders, say researchers, raising further concerns about the practice.

While there is broad agreement that ketamine-like drugs hold considerable promise as a novel antidepressant, two US psychiatrists warn that prescribing it off-label is premature.

Writing in JAMA, they say any enthusiasm for the treatment should be coupled with caution given the “limitations of the existing knowledge base and the potential adverse effects of long-term