Many patients given wrong anticoagulant dose

One in eight patients taking direct-acting oral anticoagulants (DOACs) for atrial fibrillation is being given the wrong dose, which is associated with poorer clinical outcomes, a US study shows.

The ‘real world’ review of nearly 6000 patients taking DOACs found that 9.4% were being overdosed and 3.4% were receiving too little.

Overdosing was linked to an almost twofold increase in overall mortality, while underdosing was associated with a 25% increase in hospital admissions.

The results were similar regardless of the DOAC being used, with more than half the patients

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