New prostate risk tool will help with PSA quandary

One-off test in early life guides men on whether to undergo screening

Decisions on whether to offer PSA screening can be guided by a new genetic tool that provides a personalised prediction of the age of onset of aggressive prostate cancer, researchers say.


The polygenic hazard score, which is based on 54 gene polymorphisms associated with increased risk of prostate cancer, has been validated in a major international study as a reliable predictor of if and when an individual will develop aggressive prostate cancer.

After identifying the high-risk polymorphisms from more than 20,000