New prostate risk tool will help with PSA quandary

One-off test in early life guides men on whether to undergo screening

Decisions on whether to offer PSA screening can be guided by a new genetic tool that provides a personalised prediction of the age of onset of aggressive prostate cancer, researchers say.

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The polygenic hazard score, which is based on 54 gene polymorphisms associated with increased risk of prostate cancer, has been validated in a major international study as a reliable predictor of if and when an individual will develop aggressive prostate cancer.

After identifying the high-risk polymorphisms from more than 20,000

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