A new way to treat intractable hypertension

Researchers are confident their discovery will change clinical practice

Researchers have discovered that aldosterone may be a cause of treatment-resistant hypertension.

BP

Their six-year trial of 314 patients shows the hormone causes salt to accumulate in the bloodstream.

But this overload can easily be treated with certain types of diuretics.

The research shows that mineralocorticoid receptor blockade by spironolactone (a steroid blocker of aldosterone) overcomes the salt retention and resistance of hypertension to treatment.

For patients unable to tolerate spironolactone, amiloride “seems to be as effective”, the researchers say.

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