Ongoing, unhappy and angry state of ‘ACID’

As psychiatrists, we have been struck by the number of patients referred to us who have been treated with antidepressant therapy only to find that after a period of treatment, depression appeared to substantially worsen. Further attempts at augmenting treatment with increased doses or alternative antidepressants frequently resulted in further deterioration.

In our evaluation, it was likely that some of these patients were suffering from ACID (antidepressant-associated chronic irritable dysphoria), a term introduced by American