PPI use increases risk of C. diff
PPIs increase the risk of recurrent Clostridium difficile infection by more than half, according to a meta-analysis.
The JAMA study reviewed data from more than 7000 patients with C. difficile infection from 16 observational studies.
Almost 20% of patients in the study developed recurrent C. difficile infection, and in subgroup analysis, the risk of recurrent infection was 66% higher for PPI users compared with non-users.
The US researchers noted that gastric acid suppressants altered the gut microbiome to decrease