Progesterone pessaries 'an ineffective treatment'

New findings call into question their use for preterm birth prevention

A major rethink is needed on the use of progesterone pessaries for preterm birth prevention, say researchers who found they had no benefit on birth outcomes or neonatal morbidity.


Although vaginal progesterone pessaries have become widely used in pregnancy, a trial carried out in maternity units in Australia, New Zealand and Canada has shown they have no effect on neonatal respiratory distress.

In the study, 784 women at high risk of preterm birth (based on a previous preterm birth) were randomised to self