Prostate cancer therapy linked to heart failure

Risk of heart failure was 72% higher in those treated with ADT compared with those who weren't

The use of androgen-deprivation therapy (ADT) in men with prostate cancer is associated with an increased risk of heart failure, researchers from Taiwan report.

Previous studies have suggested an association between ADT and heart failure, but only one has included Asian men in the study population, according to Taiwanese researchers.

The researchers used the Taiwan Longitudinal Health Insurance Database to investigate the relationship of 1244 men with prostate cancer who received ADT and 1806 men with prostate cancer who did not receive the therapy.

The incidence of heart failure per 100 person-years within the one-year follow-up period was more than twice as high among men receiving ADT (4.00) than among men not receiving ADT (1.89).

After adjusting for age, urbanisation level, geographical location, monthly income and comorbidities, the risk of heart failure was 72% higher in men on