Reduce antipsychotic doses in non-smokers: study

Doses of commonly prescribed antipsychotics can be reduced by as much as half in patients who do not smoke, according to Japanese researchers.

Writing in this month’s BMJ Open the researchers from Kumamoto University noted that smoking rates were typically higher in patients with schizophrenia, with research showing that cigarettes increases CYP1A2 activity, which in turn decreases the blood concentrations of many drugs including olanzapine and clozapine. 

Many studies have looked at these effects, yet none have reached a definitive agreement on whether and by how