Researchers call for alteplase rethink

The anti-clotting drug alteplase should be used no more than three hours after an acute ischaemic stroke, say researchers.

Current guidelines support its use in thrombolysis for up to 4.5 hours, but Dr Brian Alper and colleagues have found inconsistencies in the data.

While some data supports an increase in good functional outcome at three months, others show a worse functional outcome at six months, the research team from Dynamed, a clinical resource company, write in The BMJ.