Study ends debate over progesterone and miscarriage

Progesterone supplements in the first trimester of pregnancy do not improve outcomes in women with a history of unexplained recurrent miscarriages, according to the results of a new trial.

The findings mark the end of a five-year trial and provide a definitive answer to 60 years of uncertainty on the use of progesterone treatment for women with unexplained recurrent losses, say the researchers.

The study of 826 women with previously unexplained recurrent miscarriage shows those who received progesterone treatment in early pregnancy were no less likely to miscarry than those who received a placebo. This was