Study links two SSRIs to birth defects

The antidepressants fluoxetine and paroxetine should not be used first-line in women who may become pregnant, Australian researchers suggest after their meta-analysis found the SSRIs were linked to major birth defects.

The results contradict earlier studies that concluded fluoxetine was not teratogenic and may be a safer alternative to paroxetine.

The analysis of 29 studies and 69 data samples found both SSRIs were associated with a small but significantly increased risk of major fetal