Study raises new concerns about PPI risks

Proton pump inhibitors (PPIs) put patients at risk of premature death, according to a longitudinal observational study published in BMJ Open.

A team of researchers analysed the data of more than six million people obtained from the US Department of Veterans Affairs to compare the risk of death among those using PPIs or H2 blockers.

The health of participants was tracked for almost six years until 2013 or death, whichever came first.

Those taking PPIs had a 25% increased likelihood of death within a six year period than those taking H2 blockers.

This risk increased with duration of use.

While far from conclusive, the researchers say the "compelling" findings add to a growing body of evidence showing a "host of adverse events" associated with PPI use.

"Exercising pharmacovigilance and limiting PPI use to instances and durations where it is medically indicated