Study tackles controversy over SSRIs in pregnancy

Antidepressant use in late pregnancy may be associated with a small increased risk of persistent pulmonary hypertension of the newborn (PPHN), research shows.

However, the absolute risk was small and the risk increase appears more modest than suggested in previous studies, write the study authors in JAMA.

Persistent pulmonary hypertension of the newborn is associated with substantial illness and death: 10% to 20% of affected infants will not survive.  Those who do survive face serious long-term consequences, including chronic lung disease, seizures, and neurodevelopmental problems.

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