Which antidepressants work best?

All are more effective than placebo, but some are better than others

Antidepressants are indeed more effective than placebo for treating depression, a meta-analysis of 522 randomised controlled trials confirms.

Pills question mark

But some do the job better than others.

Comparing 21 commonly used antidepressants, the UK study concludes that all are more effective than placebo for the short-term treatment of acute depression in adults, with effectiveness ranging from small to moderate for different drugs.

Published in the Lancet, the study includes 87,052 people randomly assigned to a drug and 29,425 to placebo.