Why off-label antidepressant use is a bad idea

Most off-label antidepressant prescriptions lack strong scientific evidence, research finds.

Yet, around one-third of these drugs are prescribed for off-label conditions — most commonly pain, insomnia and migraine.

A Canadian study of over 100,000 antidepressant prescriptions found that tricyclic antidepressants (TCAs) had the highest prevalence of off-label indications, while SSRIs and SNRIs were less likely to be prescribed off-label.

Among all off-label antidepressant prescriptions, only 16% were directly supported by strong scientific evidence backing the