Why lithium so often fails patients
Researchers believe they are closer to knowing why so many bipolar patients don’t respond to lithium treatment.
It’s well known that about 30% of patients are only partially responsive to the drug, more than a quarter show no clinical response, and others have significant side-effects to lithium.
But the underlying biological mechanism behind these reactions has been unclear.
Now a team from Adelaide University say the answer may lie in the patients' genetic makeup.
Professor Bernhard Baune has led a study in which bipolar patients with a poor response to lithium all shared