Why tamper-resistant oxycodone is a disappointment

Experts suggest it’s time for a new approach

Tamper-resistant oxycodone tablets have not worked as well as expected, according to a study of the impact of the new formulations on opioid use and harm in Australia.

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While people who inject drugs are less likely to tamper with the tablets, which are more difficult to crush or dissolve, rates of opioid use and harm at a population level remained unchanged.

Specifically, the researchers found reduced sales of higher strengths of controlled-release oxycodone and increased sales of other oxycodone formulations. 

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