Women with HFrEF do better on lower-dose meds

A sex-specific approach to therapy is needed, researchers say

Women with heart failure achieve significantly better outcomes from half the recommended dose of ACE inhibitors, angiotensin-receptor blockers and beta blockers than men, a Dutch-led study suggests.

old woman with pills

The landmark findings, published in the Lancet, challenge the conventional ‘one-size-fits-all’ approach to treating heart failure and could have important implications for sex-specific target doses, the researchers say.

They analysed data from a prospective European study of 1720 patients (24% women) with chronic