12 measures to curb inadvertent methotrexate overdoses

A TGA committee has recommended a wide-ranging series of measures to address the ongoing problem of patients taking excessive doses of methotrexate.

The regulator’s Advisory Committee on Medicines (ACM) has expressed concern that there appears to be no letup in patients mistakenly taking daily doses of the drug that is intended for once-weekly low doses in rheumatoid arthritis.

“Avoidable methotrexate dosing errors continue to cause significant harm to a small number of patients, mainly due to inadvertent daily ingestion,