'Extra vigilance' urged in patients with psychotic major depression

DOCTORS should be extra vigilant about suicidal behaviour in patients with major depression who have psychotic symptoms, researchers warn after analysing data from a 10-year follow-up study.

UK and Australian researchers traced 72 patients with baseline psychotic major depression (PMD), 218 with schizophrenia, and 70 with bipolar or mania with psychotic symptoms, who were enrolled in a cohort study in two areas of the UK in 2006.

Forty-five patients were lost to follow-up, of whom 24 had died.  The researchers also