Insulin risk for metformin patients

Adding insulin to therapy of patients whose type 2 diabetes is not controlled by metformin may increase cardiovascular risk and mortality rates compared to adding a sulfonyurea, US research shows.

    A retrospective study of 178,341 patients taking metformin monotherapy compared outcomes in 2948 who added insulin and 39,990 who added a sulfonylurea.

    After an average follow up of 14 months, rates