PPIs: When is the right time to step down?

Experts warn deprescribing should only be on a case-by-case basis

A PBAC review of proton pump inhibitor prescribing has highlighted the lack of consensus among clinicians on the risk of adverse events with long-term use of the drugs.

woman with reflux

Research demonstrating associations between prolonged proton pump inhibitor (PPI) therapy for gastro-oesophageal reflux disease (GORD) and a plethora of adverse events, from hip fracture to pneumonia, leaves doctors wondering how to translate the findings into clinical practice.

Some specialists are worried there is the potential for inappropriate deprescribing.