TGA update highlights 130 hyponatraemia cases

MORE than 130 reports of medication-related hyponatraemia have been reported to the TGA in the last two years.

In the latest Medicines Safety Update, the TGA says drug combinations are suspected in many reports, with combined diuretic and ACE inhibitor, or diuretic and angiotensin receptor blocker, accounting for 41 reports.

Thiazide diuretics were the most commonly reported agent linked to hyponatraemia but other commonly reported drug classes included antidepressants, with 22 reports implicating SSRIs and 20 reports about serotonin