Updated warning on antipsychotics in pregnancy
WARNINGS on the use of antipsychotics during the third trimester of pregnancy are being updated on labels of all drugs in this category, the TGA says.
Product information (PI) will now warn about the risk of neonatal extrapyramidal signs (EPS), such as dyskinetic movements, and withdrawal symptoms.
Up to May 2011, the TGA had received 19 reports of EPS or withdrawal symptoms in neonates, with an atypical antipsychotic suspected in 18 reports, the regulator said in a Medicines Safety Update.
Many cases were confounded by concomitant use of other psychotropic medication, but antipsychotic